These clues are extremely helpful, especially on the 5x5's but the concept is the same.
Example "The Clue" - The 4 people are Jim, the one who left monday, the preacher and the one who ate shrimp.
Looking at the grid find where all four of the items (Jim, Monday, Preacher, Shrimp) intersect and put an X in all the squares where these items intersect individually.
When you get done with the clue you should have 6 X's on the board on a 4X4 puzzle and 9 X's on a 5X5.
I find it helpful to do this particular clue first since you have a clean grid to work with.
Hope this helps.